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Read Wisdom from the Past: Nixtamalization of Corn (the Nourishing Gourmet) andTortilla Reform
Basically, early Native Americans thousands of years ago somehow made the connection that if ashes from the fire were put in with the rock-hard kernels of corn in water, the hard outer hull would easily dissolve in the water, and the corn could then be ground and eaten. While they thought they were just making it grindable, they were also actually creating a chemical process that allows the nutrient vitamin B3, or niacin, to be released. This helped them stay healthy and thriving, and create some of the greatest civilizations of the Ancient World.
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When people came to the New World, with the terrible scheme of looting gold, etc., they returned home with the corn from this distant land. What they didn't take with them, though, were the primitive cooking practices of the Native Americans. They just ground the corn (as we do today in America, probably, to make corn meal and grits). The people in Europe and Africa ended up getting Pellegra! What's that? Diarrhea, dimentia, and death. Serves you right for spoiling all the Natives' goods. I believe people in the southern states still get pellegra today from eating lots of corn but not nixtamalizing it.
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Read more about Maseca or "Masa Flour".
Note: the corn used anciently in America was nothing like the corn we grow in Iowa (see King Corn). The corn in Iowa is genetically modified to be herbicide resistant, etc., and with a much lower protein content and larger endosperm, or starch value. It is processed using sulfuric acid, not calcium hydroxide ("lime"), to make high fructose corn syrup. Unwittingly killing ourselves again?...
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